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KMID : 0357920060400050326
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Korean Journal of Pathology
2006 Volume.40 No. 5 p.326 ~ p.332
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Significance of Galectin-3 Expression in Pulmonary Non-Small Cell Carcinoma
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Shin Dong-Hoon
Lee Chang-Hun
Kang Hyun-Jeong
Sol Mi-Young
Lee Min-Ki
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Abstract
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Background: Non-small cell carcinoma (NSCC) has become the leading cause of cancer related death around the world. However, its prognostic factors remain poorly defined. Galectin-3 is an apoptosis related protein and its relationship with various cancers is presently the subject of research. This study was performed to investigate galectin-3 expression in NSCC and its value as a prognostic factor.
Methods: We examined the expression of galectin-3 and bcl-2 in surgically resected, lung NSCC, including 61 squamous cell carcinomas and 41 adenocarcinomas. PCNA staining was also performed.
Results: Each type of carcinoma showed cytoplasmic positivity in 18 (30.0%) and 25 (61.0%) cases, respectively. Squamous cell carcinoma showed increased galectin-3 expression in better differentiated tumors, whereas adenocarcinoma didn’t show any relationship with the degree of differentiation. The cytoplasmic positivity of galectin-3 in both types of carcinoma was associated with poor prognosis. Bcl-2 expression didn’t show any significant relationship with overall survival. Galectin-3 and bcl-2 expressions were positively correlated. However, co-expression of both proteins was not related to prognosis.
Conclusions: These results indicate that galectin-3 expression in NSCC warrants attention as a possible prognostic factor.
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KEYWORD
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Non small cell lung carcinoma, Galectin 3
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